High-Throughput Screening & Automation

High-Throughput Screening & Automation

For our clients that require high-throughput screening (HTS) of clinical study samples and assays, we have the following automation in place to analyze more samples, faster, and with better precision and accuracy:

Luminex 200 System

Our Luminex 200 System automates immunoassays and bioassays for biomarker screening and protein analysis to support preclinical research and clinical diagnostic research. The system can multiplex up to 100 analytes in a single well of a 96-well microplate. The simultaneous measurement of multiple targets in each sample decreases sample volume requirements, generates more information on interrelationships between analytes within a single sample, and reduces assay reagent volume, expense and labor.

The system delivers fast and cost-effective bioassay and immunoassay results on many assay formats, including: biomarker assays, protein concentration determination and disease panel profiling, antigen arrays for serology assays, gene expression and genotyping assays, microRNA assays, transcription factor profiling, and receptor specificity assays.

TECAN Freedom EVO Liquid Handling Platform

Our TECAN Freedom EVO liquid handling platform automates microplate-based ELISAs, streamlining sample analysis while also providing maximum accuracy, reproducibility, and fast data turnaround times. The platform allows simultaneous processing of multiple microplates in one run and can process 3,000 to 18,000 assays per day depending on the assay format. Dynamic scheduling software enables hands-free automation from sample distribution to detection of the assay signal for a wide variety of ELISA protocols.

Spark Holland Symbiosis on-line SPE Systems

We have three Spark Holland Symbiosis on-line SPE systems capable of processing samples with little to no sample preparation by our scientists. Samples are processed during the previous injection’s chromatographic run time. Typical methods will allow automated analysis of 1,000 samples per day or more depending on how quickly the analytes can be chromatographed.

Waters ACQUITY UPLC Systems

We have six Waters ACQUITY UPLC systems capable of increasing sample throughput, reducing solvent use, and performing complex separations more quickly than traditional HPLC systems. Their sample organizers are capable of shuttling up to 22 well plates into the sample manager for analysis, increasing the level of automation and sample processing throughput. Samples processing can be streamlined through 96 well plate SPE or SLE followed by analysis by UPLC coupled with MS/MS detection. The UPLC systems are capable of unattended sample analysis for days allowing night and weekend instrument time to be utilized more effectively.