Bioanalytical Services (LC/MS/MS, HPLC/UV)

a senior analytical scientist conducting bioanalytical analysis on specimen samples collected during a preclinical drug development study according to a method that was developed and validated at MicroConstants

MicroConstants is the largest bioanalytical LC/MS/MS service provider on the West Coast of the United States housing 16 LC/MS/MS systems and occupying 34,000 square feet of office and laboratory space in San Diego, California.

Our Bioanalytical Chemistry Department specializes in developing and validating robust bioanalytical methods for PK/TK sample analysis of small molecules, proteins, peptides, and metabolites using LC/MS/MS (HPLC or UPLC), HPLC/UV, and fluorescence detection. We have experience analyzing API and metabolites in more than 25 different biological matrices and can provide bioanalytical support throughout all the stages of drug development.

Bioanalytical Services

Method development
Method validation
Method transfer

Early discovery bioanalysis
GLP sample analysis
Clinical sample analysis

Matrices Analyzed

MicroConstants has experience analyzing the following matrices:

Whole blood
Brain tissue
Synovial fluid
Serum
Muscle tissue
Gastric fluid
Plasma
Lung tissue
Cerebrospinal fluid (CSF)
Urine
Liver tissue
Bronchial lavage fluid
Fecal homogenate
Kidney tissue
Sputum
Spinal cord homogenate
Ocular tissue
Endothelial lining fluid (ELF)
Tumor homogenate
Vitreous fluid
Bone marrow
Aorta homogenate
Aqueous humor
Perilymph

Types of Studies Supported

Preclinical studies

Discovery PK
Toxicokinetic studies
Tissue distribution studies

Clinical studies

Phase I-IV
Clinical pharmacology studies
Drug-drug interaction studies
BA/BE studies