Upcoming Events & Poster Presentations
8th annual Workshop on Recent Issues in Bioanalysis (WRIB)
On March 10th – 14th, several MicroConstants employees will be in Los Angeles, CA for the 8th WRIB. The workshop will focus on new challenges in method development, emerging approaches for regulated bioanalysis, and the latest regulatory updates/findings on multiple harmonized guidances around the globe. If you plan to attend, be sure to stop by our table (#3) and say hello.
In addition to an exhibit table, one of our senior staff scientists, Gregory Reynolds, will be presenting a poster on Validated Multi-site GLP-compliant Analysis of Solithromycin (SOLI) in Monkey Plasma Samples Following Filtration to Remove Potentially Active Anthrax Spores (Poster #T11). The poster will be displayed from Tuesday, March 11th at 8am until Wednesday, March 12th at Noon; however, the PDF is already available on our website.
View this poster.
American Association of Pharmaceutical Scientists (AAPS) National Biotechnology Conference
In May, MicroConstants will be exhibiting at the 2014 AAPS National Biotechnology Conference in San Diego, CA. If you plan to attend and would like to arrange a time to meet during the conference or even tour our facility (which is approximately 20 minutes north of the conference venue), please email Ron Shevock. Otherwise, be sure to visit our table (#131) during the conference to say hello.
MicroConstants in the News
Interview with David Beyerlein on Multi-site Validation and the 8th WRIB
Our VP of Global Operations, David Beyerlein, recently spoke with Bioanalysis Zone on multi-site validation to safely remove anthrax spores from study samples, which is the topic of the poster we will be presenting at the 8th annual Workshop on Recent Issues in Bioanalysis (WRIB) next week.
Publication in the ACS Medicinal Chemistry Letters
One of our DMPK scientists, Rishi Sharma, Ph.D., co-authored a paper on C-Ring Cannabinoid Lactones: A Novel Cannabinergic Chemotype that was published in the ACS Medicinal Chemistry Letters in January. The paper was a result of his graduate research at Northeastern University.
Read this publication.
Blood-to-Plasma Partition Ratio Determination
MicroConstants performs blood-to-plasma partition ratio studies to determine the blood-to-plasma ratio for test articles. Knowing the distribution of a drug candidate between red blood cells and plasma is useful for a number of reasons, including the explanation of variability in measured plasma concentrations due to hemolysis. Additionally, compounds that preferentially distribute into red blood cells may have over-predicted clearance values based on plasma concentrations. Therefore, determining the blood-to-plasma ratio is important for deciding whether plasma or whole blood would provide more physiologically relevant pharmacokinetic parameters. For these studies, chloroquine is used as a positive control.