Protein Simple Ella

For Complex Multiplex Biomarker Analysis
BioAgilytix offers Ella™, from ProteinSimple®, a Bio-Techne® brand, as part of our extensive technology suite supporting complex biomarker work. Our scientists typically turn to Ella for multiplex biomarker analysis in cases where assay variability and antibody cross-reactivity are of particular concern. This platform standardizes sample preparation to ensure each assay is consistently and reproducibly run.

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The Ella platform conducts immunoassay testing within a microfluidic Simple Plex™ cartridge. It automates the immunoassay by running samples in parallel through individual microfluidic channels, binding the protein of interest before washing off unbound analyte and adding a detection reagent. Each channel has three Glass Nano Reactors (GNRs) that are coated with a capture antibody so that results are produced in triplicate for each sample.

Ella uses fluorescence detection to enable measurement of low endogenous levels of proteins across a wider and more sensitive detection range. It also precisely controls volume on every assay, resulting in low, single-digit coefficients of variation (CVs).

Why BioAgilytix for Small and Large Molecule Bioanalysis?

Our passion for the science of small and large molecule bioanalysis drives our ability to deliver premium, tailored services for biomarker, immunogenicity, pharmacokinetics (PK), and cell-based assays.


The Ella platform is able to deliver highly sensitive, reproducible results with low sample volumes. By automating assay runs, it eliminates manual steps for washes and reagent additions, as well as the chance of pipetting errors. This reduces assay variability while speeding analysis time.

Ella’s high sensitivity also makes it valuable for immunoassay studies where limited sample volume is available. Each Simple Plex™ assay yields three results from each microfluidic channel’s three GNRs, helping to maximize each aliquot of sample.

Top Benefits of Ella

  • Automation
  • High Sensitivity
  • Multiplexing
  • Reduced Cross-Reactivity
  • Reproducible Results
  • Low Sample Volume

Biomarker Insight

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Ella is part of BioAgilytix’s extensive portfolio of bioanalytical technologies and automation systems supporting our core immunoassay services. As a world-class provider of biomarker services, we often deal with complex assay demands, and the Ella platform prepares us to address our customers’ multiplex biomarker analysis challenges effectively. We are continuously optimizing our support for biomarker studies, and Ella equips us with an advanced tool to quickly and effectively deliver the quality results our customers require.

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